021-51111890
购物车（）
sales@molnova.cn
Ro 48-8071 fumarate
CAS No. 189197-69-1
Ro 48-8071 fumarate ( Ro-488071 fumarate )
产品货号. M12966 CAS No. 189197-69-1
A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥365 | 有现货 |
|
| 10MG | ￥551 | 有现货 |
|
| 25MG | ￥810 | 有现货 |
|
| 50MG | ￥1021 | 有现货 |
|
| 100MG | ￥1677 | 有现货 |
|
| 200MG | ￥2179 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Ro 48-8071 fumarate
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
-
产品描述A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
-
同义词Ro-488071 fumarate
-
通路Others
-
靶点Other Targets
-
受体Oxidosqualenecyclase
-
研究领域Cardiovascular Disease
-
适应症Dyslipidemia
化学信息
-
CAS Number189197-69-1
-
分子量564.44
-
分子式C27H31BrFNO6
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 55 mg/mL
-
SMILESO=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
-
化学全称Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
产品手册
关联产品
-
KN-93 Phosphate
KN-93 Phosphate is a potent and specific CaMKII inhibitor (Ki: 0.37 μM), no inhibitory for PKC, APK, MLCK or Ca2+-PDE activities.
-
Ondansetron HCl
Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
-
Microgrewiapine A
Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
