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Ro 48-8071 fumarate
CAS No. 189197-69-1
Ro 48-8071 fumarate ( Ro-488071 fumarate )
产品货号. M12966 CAS No. 189197-69-1
A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥365 | 有现货 |
|
| 10MG | ￥551 | 有现货 |
|
| 25MG | ￥810 | 有现货 |
|
| 50MG | ￥1021 | 有现货 |
|
| 100MG | ￥1677 | 有现货 |
|
| 200MG | ￥2179 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ro 48-8071 fumarate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
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产品描述A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
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同义词Ro-488071 fumarate
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通路Others
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靶点Other Targets
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受体Oxidosqualenecyclase
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研究领域Cardiovascular Disease
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适应症Dyslipidemia
化学信息
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CAS Number189197-69-1
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分子量564.44
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分子式C27H31BrFNO6
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 55 mg/mL
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SMILESO=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
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化学全称Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
产品手册
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